Key Takeaways
- Pairwise has expanded its gene editing platform, particularly in specialty crops, showing a significant surge in demand with over 25 licensees.
- The regulatory landscape for gene editing is improving globally, with a focus on making the process more akin to conventional breeding.
- Pairwise is innovating in various areas, including perennial crops, insects, and livestock, highlighting a broader application of CRISPR technology beyond traditional crops.
Expansion of Gene Editing
Gene editing technology is gaining traction beyond row crops, with Pairwise reporting a significant increase in licensing agreements for its Fulcrum platform, now covering over 30 species through 25 licensees in various agricultural sectors. Chief Operating Officer Ian Miller notes that gene editing, unlike traditional genetic modification, manipulates species’ native genes, thus simplifying regulatory pathways and fostering interest particularly in Europe with new regulations for genomic techniques.
Pairwise, founded in 2017 by leaders in agricultural biotechnology and CRISPR innovation, is collaborating with industry giants like Bayer and Corteva to explore functions such as enhancing corn varieties and reducing disease susceptibility in soybeans. The Fulcrum platform is also attracting partnerships in diverse areas, from cassava and cacao to pest control and livestock genetics, revealing a demand for genetic solutions across the agricultural spectrum.
Miller mentions that behind the current licensees, many more entities are in various discussion stages, indicating a robust interest in gene editing solutions. For instance, Agragene utilizes Fulcrum for developing sterile insects for pest management, while other partners are focusing on livestock, aquaculture, and microbial applications.
Gene Editing Toolbox and Accessibility
Fulcrum is likened to a word processor for DNA, allowing for precise edits through multiple editing techniques. This flexibility is beneficial as Pairwise actively employs multiplex editing, enabling simultaneous changes to multiple genes.
Miller emphasizes a strategic business model that provides a single licensing framework for multiple gene-editing tools, aiming to reduce complexity and encourage innovation. The licensing approach includes upfront fees and royalties tied to product commercialization, thus facilitating user engagement and technology transfer.
Focus on Perennial and Specialty Crops
Particularly notable is the potential for gene editing in perennial crops and specialty varieties, which traditionally face lengthy breeding cycles. Through gene editing, Pairwise aims to expedite agricultural innovation by circumventing time-consuming processes. For instance, new blackberry varieties with modified traits such as compact growth and seedless quality are in the pipeline, showcasing the platform’s capabilities.
While gene editing presents exciting possibilities, Miller clarifies that it will not replace conventional breeding methods; rather, it complements them by facilitating precise genetic variation. Gene editing also allows researchers to leverage understanding from well-studied crops to improve others, leading to potential breakthroughs in agricultural genetics.
The Future of CRISPR in Agriculture
Despite challenges posed by less investment in certain crops, Pairwise’s work suggests that CRISPR technology can play a far-reaching role in agriculture. The company’s ongoing projects, including work on yams with the International Institute of Tropical Agriculture, illustrate a growing focus on broader genetic applications.
Miller maintains optimism regarding the future of CRISPR in agriculture, indicating that the technology’s evolution will extend beyond traditional staples like corn and soybeans. The widening scope of opportunities points to an exciting new chapter for gene editing in agricultural innovation, particularly in developing countries where such advancements could have significant impacts.
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